Criteria for the classification of monoclonal gammopathies.
Diagnosis of monoclonal gammopathy of renal significance Frank Bridoux1, Nelson Leung2,3, Colin A. Hutchison4, Guy Touchard1, Sanjeev Sethi5, Jean-Paul Fermand6, Maria M. Picken7, Guillermo A. Herrera8, Efstathios Kastritis9, Giampaolo Merlini10, Murielle Roussel11, Fernando C. Fervenza2, Angela Dispenzieri3, Robert A. Kyle3, Samih H. Nasr5 on behalf of the International Kidney and Monoclonal.
Overview. Amyloidosis (am-uh-loi-DO-sis) is a rare disease that occurs when an abnormal protein, called amyloid, builds up in your organs and interferes with their normal function.
Alternatives to Using Human Experience in Assessing Health Risks Rall, D P; Hogan, M D; Huff, J E; Schwetz, B A; Tennant, R W 1987-05-01 00:00:00 Clinical and epidemiologic studies, which frequently involve the observation and evaluation of human experience with exposure to possibly hazardous agents, obviously offer the most direct means of assessing the human health risks associated with such.
The Kidney in Plasma Cell Dyscrasias Contributions to Nephrology Vol. 153 Series Editor Claudio Ronco Vicenza The Kidney in Plasma Cell Dyscrasias.
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes) is a rare multi-systematic paraneoplastic disorder due to an underlying plasma cell disorder. The diagnosis of POEMS syndrome requires the presence of both mandatory criteria (a chronic polyneuropathy and a monoclonal plasma cell-proliferative disorder, always lambda restricted); at least one major.
This disorder can appear as an idiopathic dermatosis, usually in young women, but occasionally it is associated with diseases such as anorexia, intestinal lymphoma, chronic myelomonocytic leukemia, monoclonal gammopathies, cryoproteinaemia, viral infections, as well as connective tissue diseases, especially lupus, picture that is known as chilblain lupus. We present a case of perniosis.
In general, when plasma cells become cancerous and grow out of control, this is called multiple myeloma. The plasma cells make an abnormal protein (antibody) known by several different names, including monoclonal immunoglobulin, monoclonal protein (M-protein), M-spike, or paraprotein.